Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma

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Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma

BACKGROUND Ewing sarcoma (EWS) is a malignant tumour of bone and soft tissue, and although many patients are cured with conventional multimodal therapy, those with recurrent or metastatic disease have a poor prognosis. Genomic instability and programmed cell death ligand-1 (PD-L1) expression have been identified in EWS, providing a rationale for treatment with agents that block the programmed c...

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Current Therapeutic Approaches in Metastatic and Recurrent Ewing Sarcoma

Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches...

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ژورنال

عنوان ژورنال: Journal of Hematology & Oncology

سال: 2016

ISSN: 1756-8722

DOI: 10.1186/s13045-016-0278-x